A Simple Observation Led to Industry-Changing Technology

The technology that appeared to change the way local fat is managed was based on a simple observation: some children got dimples due to eating popsicles.

scientific studies

The idea that cold can selectively affect fat was the theory behind the proven Cryolipolysis science on which the CoolSculpting technology was developed.

The CoolSculpting procedure is the non-invasive cooling of adipose tissue to induce lipolysis – the breaking down of fat cells – so as to reduce body fat without damage to other surrounding tissues. The scientific principles on which the CoolSculpting procedure was based were discovered by dermatologists Dieter Manstein and Rox Anderson, Professors of Dermatology of Harvard Medical School.

Research conducted by the American Dermatologists demonstrated that under carefully controlled conditions, subcutaneous fat cells are naturally more vulnerable to the effects of cold as compared to the surrounding tissues.

Their initial work that was published in the scientific journal Lasers in Surgery and Medicine in November 2008, demonstrated the following:

  • Exposure of fat cells to cooling causes their apoptosis – a natural, controlled cell death – which leads to the release of cytokines and other inflammatory mediators that gradually eliminate the affected cells.
  • Inflammatory cells digest the affected fat cells in the months after the procedure, reducing the thickness of the fat layer.
  • Lipids from the fat cells are released and transported slowly by the lymphatic system to be processed and eliminated by the body, much like that of fat from food.

Based on their research, the scientists concluded that “prolonged and controlled local tissue cooling can induce selective fat cell reduction and subsequent loss of subcutaneous fat, without damaging the overlying skin.” This discovery, called “selective Cryolipolysis”, led to the development of the patented CoolSculpting technology.


  • Efficacy & safety demonstrated in studies

Avram MM, Harry RS. Cryolipolysis® for Subcutaneous Fat Layer Reduction. Lasers Surg Med.

  • Cryolipolysis® reduces excess adipose tissue

Nelson AA, Wasserman D, Avram MM. Cryolipolysis® for the Reduction of Excess Adipose Tissue. Semin Cutan Med Surg.

  • Proof of concept for Cryolipolysis®

Manstein D, Laubach H, Watanabe K, et al. Selective Cryolysis: A Novel Method of Noninvasive Fat Removal. Lasers Surg Med.

  • 22% reduction in “love handles” fat layer

Dover J, Burns J, Coleman S, et al. A Prospective Clinical Study of Noninvasive Cryolipolysis® for Subcutaneous Fat Layer Reduction

  • Decreases fat and changes body contour

Zelickson B, Egbert BM, Preciado J, et al. Cryolipolysis® for Noninvasive Fat Cell Destruction: Initial Results From a Pig Model. Dermatol Surg.

  • No impact on lipid & liver function

Klein KB, Zelickson B, Ropelle JG, et al. Noninvasive Cryolipolysis® for Subcutaneous Fat Reduction Does Not Affect Serum Lipid Levels or Liver Function Tests. Lasers Surg Med.

  • No evidence of long-term nerve injury

Coleman SR, Sachdeva K, Egbert BM. Clinical Efficacy of Noninvasive Cryolipolysis® and Its Effects on Peripheral Nerves. Aesthetic Plast Surg.

  • Visible improvement & high patient satisfaction

Dierickx CC, Mazer JM, Sand M, et al. Safety, Tolerance, and Patient Satisfaction With Noninvasive Cryolipolysis®. Dermatol Surg.

  • Long-term follow-up shows lasting results

Bernstein EF. Longitudinal Evaluation of Cryolipolysis® Efficacy. J Cosmet Dermatol.

  • Significant clinical practice business growth

Stevens WG, Pietrzak LK, Spring MA.Broad Overview of a Clinical and Commercial Experience With CoolSculpting. Aesthetic Surg J.